Description

Mequinol is a synthetic derivate of hydroquinone, and depigmenting agent used to lighten the skin as it’s used for skin depigmentation. As a topical drug mequinol is often mixed with tretinoin, a topical retinoid as a prescription skin lightener.  Mequinol, also known as 4-hydroxyanisole or Hydroquinone mono methyl ether (MEHQ),  is less irritating than hydroquinone and is not cytotoxic to human melanocytes.
It can be combined with ascorbyl palmitate, to enhance skin lightening.
A clinical trial performed on a group of 595 subjects (486 women and 109 men) with solar lentigines was able to demonstrate the value of this combination. It is often mixed with tretinoin, a topical retinoid.

Mequinol is a Skin Lightening Agent. The mechanism of action is as a Melanin Synthesis Inhibitor the physiologic effect is by means of Depigmenting Activity.

Melting Point  54 °C

CAS NO: 150-76-5

It has pH-responsive solubility i.e. soluble in acidic conditions (pH < 6)
Recommended pH range for formulation:  4.5 – 7.8 (Slighty acidic to Neutral pH)

Usage rate:0.1-2%
INCI: Mequinol
Soluble in oil, ethanol, organic solvents, poorly soluble in water.

Appearance: White flake or waxy crystal
Store in a cool, dry place away from light and moisture.